Senior Manager, Reliability Engineering & Work Management

Amgen

Holly Springs, NC

Pay: $148,715-$201,203/yr

US - North Carolina - Holly Springs

JOB ID:

R-258893 LOCATION

US - North Carolina - Holly Springs

WORK LOCATION TYPE

On Site

DATE POSTED

Nov. 06, 2026

CATEGORY

Engineering

SALARY RANGE

148,715.15USD -201,202.85 USD

**Join Amgen’s Mission of Serving Patients**

--------------------------------------------

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**

SENIOR MANAGER

,

RELIABILITY ENGINEERING

&

WORK MANAGEMENT

**

=============================================================

**What you will do**

--------------------

Let’s do this. Let’s change the world. In this vital role you will be responsible for the department inclusive of asset management and reliability through the work order administrative, central inventory and reliability programs at the drug substance facility in ANC. You will be joining the Facilities & Engineering (F&E) team to partner closely with the Corporate Engineering team as well as all site functions.

This role will lead and develop a multi-functional engineering operations organization responsible for:

• Work order administration and CMMS process ownership
• Asset maintenance planning and scheduling
• Spare parts and MRO inventory strategy
• Reliability engineering and predictive maintenance programs
• Sustainability and energy optimization initiatives
• Engineering KPI and business performance reporting

Establish long-range maintenance and asset reliability strategies aligned with site operational goals, regulatory compliance requirements, and enterprise engineering standards. Build a culture centered on safety, compliance, operational excellence, accountability, and continuous improvement.

**The Senior Manager Work Order Administration CMMS Process Owner reports to the Director of the Amgen North Carolina Facilities & Engineering group.**

-------------------------------------------------------------------------------------------------------------------------------------------------------

• Lead and develop a multi-functional engineering operations organization responsible for work order administration, CMMS governance, maintenance planning and scheduling, reliability engineering, central inventory management, and KPI reporting.
• Lead the Central Inventory (equipment spare parts) program working closely with the Internal Service Provider as it relates to the overall MRO process supporting the site.
• Lead the site reliability program, aligning on the network approach for the Amgen North Carolina reliability roadmap, implementing initiatives and own engineering KPIs and business reporting on program and site equipment health.
• Establish long-range maintenance and asset reliability strategies aligned with site operational goals, regulatory compliance requirements, and enterprise engineering standards.
• Identify opportunities for continuous improvement, recommend solutions, and manage implementation of initiatives to improve planning and scheduling accuracy and adherence and overall asset management program.
• Collaborate with key customers and support groups regarding preventative maintenance activities and on time completion as well as manage aging work order backlog.
• Collaborate with corporate network groups to improve planning and scheduling performance in addition to improving programs within CMMS, Central Inventory, and Reliability to meet business needs.
• Provide direct supervision and oversight of work order safety programs and planning procedures.
• Experience working in a regulated environment (e.g. cGMP, OSHA, EPA, etc.), experience interacting with regulatory agencies and inspectors, and familiarity with GMP quality systems/processes such as change control, non-conformances, corrective and preventative actions, and qualifications/validation
• Strong leadership, technical writing, and communication/presentation skills.
• Work schedule flexibility as required to support 24/7 operations, requiring occasional after-hours engineering coverage

**What