Regeneron
Tarrytown, NY
Shift: Full time
We are seeking a dynamic senior associate scientist to join bioanalytical biomarker technologies group. The candidate will design and execute analytical and bioanalytical method to support biotherapeutics discovery and preclinical development. The individual should be experienced in executing HPLC and/or LC-MS based methods from sample preparation, instrument operation to data analysis. The successful candidate will be expected to work cross-functionally in a collaborative, fast-paced, multidisciplinary team environment and have the opportunity to explore new technologies while growing technical depth. A Typical day in this role looks like: Design, execute, and troubleshoot LC‑MS and HPLC methods for analytical characterization of bioconjugates and bioanalytical quantification of therapeutics. Support a range of modalities—including monoclonal antibodies (mAbs), antibody–drug conjugates (ADCs), siRNA/oligonucleotides, and endogenous biomarkers—across diverse biological matrices. Perform end‑to‑end sample preparation (e.g., LLE, SPE, affinity capture, enzymatic digestion, homogenization) and operate LC‑MS/MS workflows from instrument setup to data analysis. Analyze and interpret results; summarize findings, propose next steps, and present data at internal meetings. Document experiments, methods, and results in electronic lab notebooks (ELNs) with clarity and rigor; contribute to SOPs and method documentation. Maintain instruments and general lab readiness; troubleshoot systems and ensure data integrity and instrument uptime. Evaluate and implement new platforms, workflows, and automation to improve throughput, sensitivity, and robustness. Prioritize effectively across multiple projects and timelines, collaborating closely with colleagues in discovery biology, DMPK/PK‑PD, and process/analytical teams. This role may be for you, if you have experience: BS or MS degree in Chemistry, Biochemistry, Pharmaceutical Science or a related discipline with 3 years hand-on experience. Experience in liquid chromatography and/or mass spectrometry is preferred, with the ability to execute, qualify and optimize analytical methods. Hands on experience in sample preparation techniques (LLE, SPE, affinity capture, enzymatic digestion, homogenization, etc.); experience with automation platforms is a plus. Detail-oriented, good interpersonal and effective technical communication skills (written and verbal). Ability to manage multiple projects in a fast-paced environment. Collaborative team player with a growth mindset to quickly adapt to evolving priorities and continuously learn to embrace new challenges. Previous exposure in bioanalysis of LC-MS based small molecule, oligonucleotides, biomarkers and biotherapeutics assay development is beneficial. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries’ specific benefits, please speak to your recruiter. Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company s business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable l